besides the rh antibodies, what other red blood cell antibody is common to cause severe hdfn?

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• Published: 28 Oct 2017

Unusual Rhesus Antibodies as a Cause for Fetal Isoimmunisation

Journal of Fetal Medicine book 4,pages 207–209 (2017)Cite this article

Abstruse

Hemolytic disease of the newborn due to Rh isoimmunisation in a Rhesus D (Rh-D) negative female parent with an Rh-D positive fetus is a well recognised entity. Although antibiotic to Rh-D antigen (anti-D antibiotic) was once the major crusade of hemolytic disease of the fetus and newborn (HDFN), widespread adoption of antenatal and postnatal prophylactic anti-D immunoglobulin assistants has resulted in a marked subtract in the prevalence of allo-immunisation due to the Rh-D antigen during pregnancy. Yet, at the aforementioned fourth dimension, the maternal allo-immunisation to other cerise cell Rhesus antigens became more evident as a cause for HDFN, since no safety immunoglobulins are available to foreclose the formation of these antibodies. The authors written report a instance of a meaning woman with AB negative blood grouping and positive indirect Coombs test (ICT) with rising center cerebral artery peak systolic velocity (MCA-PSV) on follow upward visits. Fetus required intrauterine transfusion. Fetal cord blood sampling revealed the fetus to exist B negative and the direct Coombs test (DCT) was positive. On further testing, maternal serum was found to be positive for anti-D, anti-C and anti-G antibodies. Postnatally, the baby required double volume exchange transfusion. The authors highlight the importance of irregular antibody screening for women with obstetric history suggestive of HDNF. This could help in diagnosis and successful treatment of the afflicted fetus.

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Affiliations

1. Department of Obstetrics and Gynecology, Maulana Azad Medical College and associated Lok Nayak Infirmary, New Delhi, 110049, India

   Aastha Raheja & Krishna Agarwal

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Correspondence to Krishna Agarwal.

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Raheja, A., Agarwal, One thousand. Unusual Rhesus Antibodies every bit a Cause for Fetal Isoimmunisation. J. Fetal Med. 4, 207–209 (2017). https://doi.org/10.1007/s40556-017-0141-3

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• Received: 15 April 2017

• Accepted: nineteen September 2017

• Published: 28 October 2017

• Issue Appointment: December 2017

• DOI : https://doi.org/ten.1007/s40556-017-0141-three

Keywords

• Hemolytic affliction of the fetus and newborn
• Allo-immunisation
• Anti C antibodies
• Anti Thousand antibodies

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